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| SULFATION OF ENDOGENOUS COMPOUNDS AND XENOBIOTICS - INTERACTIONS AND FUNCTION IN HEALTH AND DISEASE |
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| Author(s): COUGHTRIE MWH, BAMFORTH KJ, SHARP S, JONES AL, BORTHWICK EB, BARKER EV, ROBERTS RC, HUME R, BURCHELL A |
| Source: CHEMICO-BIOLOGICAL INTERACTIONS Volume: 92 Issue: 1-3 Pages: 247-256 Published: JUN 1994 |
| Times Cited: 16 References: 30 |
| Abstract: Sulfation is a major detoxication mechanism for endogenous compounds and xenobiotics performed by a family of sulfotransferase isoenzymes. Understanding the normal cellular functions of these different sulfotransferases and the way in which endogenous and exogenous factors are able to influence their activity and expression will provide us with the information necessary to develop novel therapeutic strategies for conditions where sulfation may be implicated. This concept is discussed and is illustrated by examples including adverse drug reactions, fetal development and cancer. |
| Document Type: Proceedings Paper |
| Language: English |
| Reprint Address: COUGHTRIE, MWH (reprint author), UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT BIOCHEM MED, DUNDEE DD1 9SY, SCOTLAND |
Addresses:
1. UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT MED, DUNDEE DD1 9SY, SCOTLAND
2. UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT CHILD HLTH, DUNDEE DD1 9SY, SCOTLAND
3. UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT OBSTET & GYNAECOL, DUNDEE DD1 9SY, SCOTLAND |
| Publisher: ELSEVIER SCI IRELAND LTD, CUSTOMER RELATIONS MANAGER, BAY 15, SHANNON INDUSTRIAL ESTATE CO, CLARE, IRELAND |
| Subject Category: Biochemistry & Molecular Biology; Pharmacology & Pharmacy; Toxicology |
| IDS Number: PD138 |
| ISSN: 0009-2797 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |