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| DEVELOPMENTAL EXPRESSION OF A NOVEL MURINE HOMEOBOX GENE (CHX10) - EVIDENCE FOR ROLES IN DETERMINATION OF THE NEURORETINA AND INNER NUCLEAR LAYER |
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| Author(s): LIU ISC, CHEN JD, PLODER L, VIDGEN D, VANDERKOOY D, KALNINS VI, MCINNES RR |
| Source: NEURON Volume: 13 Issue: 2 Pages: 377-393 Published: AUG 1994 |
| Times Cited: 213 References: 110 |
| Abstract: Few potential regulatory proteins of vertebrate retinal development have been identified. We describe a 39 kDa murine polypeptide (Chx10) with a homeodomain 82% identical to that of the nematode protein ceh-10. In the developing mouse, the Chx10 transcript is expressed throughout the anterior optic vesicle and all neuroblasts of the optic cup. In the mature retina, the Chx10 protein is restricted to the inner nuclear layer, in which its expression decreases from the outer to the inner margin. Chx10 transcripts are also detected in regions of the developing thalamus, hindbrain, and ventral spinal cord. The data suggest that Chx10 plays critical roles in the formation of the neuroretina and in the development and maintenance of the inner nuclear layer. |
| Document Type: Review |
| Language: English |
| Reprint Address: LIU, ISC (reprint author), HOSP SICK CHILDREN, RES INST, DEPT GENET, TORONTO M5G 1X8, ON CANADA |
Addresses:
1. UNIV TORONTO, DEPT MOLEC & MED GENET, TORONTO M5S 1A8, ON CANADA
2. UNIV TORONTO, DEPT ANAT & CELL BIOL, TORONTO M5S 1A8, ON CANADA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: PD430 |
| ISSN: 0896-6273 |
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