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| THE PROTEIN ENCODED BY THE DROSOPHILA POSITION-EFFECT VARIEGATION SUPPRESSOR GENE SU(VAR)3-9 COMBINES DOMAINS OF ANTAGONISTIC REGULATORS OF HOMEOTIC GENE COMPLEXES |
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| Author(s): TSCHIERSCH B, HOFMANN A, KRAUSS V, DORN R, KORGE G, REUTER G |
| Source: EMBO JOURNAL Volume: 13 Issue: 16 Pages: 3822-3831 Published: AUG 15 1994 |
| Times Cited: 293 References: 65 |
| Abstract: Modifier mutations of position-effect variegation (PEV) represent a useful tool for a genetic and molecular dissection of genes connected with chromatin regulation in Drosophila. The Su(var)3-9 gene belongs to the group of haplo suppressor loci which manifest a triple enhancer effect. Mutations show a strong suppressor effect even in the presence of PEV enhancer mutations, indicating a central role of this gene in the regulation of PEV. By molecular analysis, Su(var)3-9 could be correlated with a 2.4 kb transcript which encodes a putative protein of 635 amino acids containing a chrome domain and a region of homology to Enhancer of zeste and trithorax, two antagonistic regulators of the Antennapedia and Bithorax gene complexes, as well as to the human protein ALL-1/Hrx which is implicated in acute leukemias. This region of homology is found in all four proteins at the C-terminus. The homology of Su(var)3-9 to both negative (Polycomb and Enhancer of zeste) and positive (trithorax) regulators of the Antennapedia and Bithorax complexes also suggests similarities in the molecular processes connected with stable transmission of a determined state and the clonal propagation of heterochromatinization. |
| Document Type: Article |
| Language: English |
| Reprint Address: TSCHIERSCH, B (reprint author), UNIV HALLE WITTENBERG, INST GENET, DOMPLATZ 1, D-06108 HALLE, GERMANY |
Addresses:
1. FREE UNIV BERLIN, INST GENET, D-14195 BERLIN, GERMANY |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: PD661 |
| ISSN: 0261-4189 |
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