| LYMPHOCYTE LIFE-SPAN AND MEMORY |
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| Author(s): SPRENT J, TOUGH DF |
| Source: SCIENCE Volume: 265 Issue: 5177 Pages: 1395-1400 Published: SEP 2 1994 |
| Times Cited: 292 References: 115 |
| Abstract: Differentiation of immature T and B cells in the primary lymphoid organs gives rise to a pool of long-lived lymphocytes that recirculate through the secondary lymphoid tissues. On the basis of their surface markers, T and B cells comprise a mixture of naive and memory cells with differing life-spans. Immunization (and vaccination) causes naive lymphocytes to proliferate and differentiate into effector cells and memory cells. Whether the survival of memory cells is innate or requires persistent contact with residual antigen is controversial. Resolving this issue may be crucial for designing optimal vaccines. |
| Document Type: Review |
| Language: English |
| Reprint Address: SPRENT, J (reprint author), SCRIPPS RES INST, DEPT IMMUNOL, IMM4, 10666 N TORREY PINES RD, LA JOLLA, CA 92037 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PE733 |
| ISSN: 0036-8075 |