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| MARKERS OF MOUSE MACROPHAGE DEVELOPMENT DETECTED BY MONOCLONAL-ANTIBODIES |
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| Author(s): LEENEN PJM, DEBRUIJN MFTR, VOERMAN JSA, CAMPBELL PA, VANEWIJK W |
| Source: JOURNAL OF IMMUNOLOGICAL METHODS Volume: 174 Issue: 1-2 Pages: 5-19 Published: SEP 14 1994 |
| Times Cited: 202 References: 77 |
| Abstract: In this review, we present and discuss a selected panel of antibody-defined markers expressed during different stages of mouse macrophage development. We distinguish four categories of markers, which are characteristic of: (1) macrophage precursors acid immature macrophages (ER-MP12, ER-MP20, ER-MP54, ER-MP58); (2) mature macrophages in general (F4/80, BM8, Mac-1, Mac-2, ER-BMDM1); (3) macrophage subsets (ER-HR3, ER-MP23, ER-TR9, Forssman antigen, MOMA-1, MOMA-2, Monts-4, SER-4), and (4) IFN-gamma-stimulated macrophages (H-2Ia, LFA-1, ICAM-1, 158.2, MBR-2, TM-2, TM-4, and TM-5). It should be noted that many of the markers in this last category are inducible by other stimuli as well. The rigid classification of markers into four separate groups should be regarded as a digitalization of a continuum, thus inevitably implicating a simplification of the complex phenotypic changes that occur during mononuclear phagocyte development. Nevertheless, the current selection of antibodies against markers for different developmental stages of macrophages constitutes an important tool for characterization of mouse macrophages which participate in various biological processes. |
| Document Type: Article |
| Language: English |
| Reprint Address: LEENEN, PJM (reprint author), ERASMUS UNIV ROTTERDAM, DEPT IMMUNOL, POB 1738, 3000 DR ROTTERDAM, NETHERLANDS |
Addresses:
1. NATL JEWISH CTR IMMUNOL & RESP MED, DIV BASIC IMMUNOL, DENVER, CO 80206 USA |
| Publisher: ELSEVIER SCIENCE BV, PO BOX 211, 1000 AE AMSTERDAM, NETHERLANDS |
| Subject Category: Biochemical Research Methods; Immunology |
| IDS Number: PH109 |
| ISSN: 0022-1759 |
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