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| THE POWER OF INTERVAL MAPPING OF QUANTITATIVE TRAIT LOCI, USING SELECTED SIB PAIRS |
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| Author(s): CARDON LR, FULKER DW |
| Source: AMERICAN JOURNAL OF HUMAN GENETICS Volume: 55 Issue: 4 Pages: 825-833 Published: OCT 1994 |
| Times Cited: 72 References: 13 |
| Abstract: The interval-mapping procedure of Fulker and Cardon for analysis of a quantitative-trait loci (QTL) is extended for application to selected samples of sib pairs. Phenotypic selection of sib pairs, which is known to yield striking increases in power when a single marker is used, provides further increases in power when the interval-mapping approach is used. The greatest benefits of the combined approach are apparent with coarse maps, where QTLs of relatively modest (15%-20%) heritability can be detected with widely spaced markers (40-60 cM apart) in reasonably sized sibling samples. Useful information concerning QTL location is afforded by interval mapping in both selected and unselected samples. |
| Document Type: Article |
| Language: English |
| Reprint Address: CARDON, LR (reprint author), STANFORD UNIV, DEPT MATH, STANFORD, CA 94305 USA |
Addresses:
1. SRI INT, HLTH SCI SECT, STANFORD, CA USA
2. UNIV COLORADO, INST BEHAV GENET, BOULDER, CO 80309 USA |
| Publisher: UNIV CHICAGO PRESS, 5720 S WOODLAWN AVE, CHICAGO, IL 60637 |
| Subject Category: Genetics & Heredity |
| IDS Number: PJ027 |
| ISSN: 0002-9297 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |