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| HOW FLIES MAKE ONE EQUAL 2 - DOSAGE COMPENSATION IN DROSOPHILA |
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| Author(s): GORMAN M, BAKER BS |
| Source: TRENDS IN GENETICS Volume: 10 Issue: 10 Pages: 376-380 Published: OCT 1994 |
| Times Cited: 25 References: 45 |
| Abstract: Dosage compensation is the process by which the expression of X-linked genes is equalized in males and females. In Drosophila, dosage compensation occurs by coordinately upregulating the transcription rates of all the genes on the single X chromosome in males. This hypertranscription requires the functioning of four autosomal male-specific lethal (msl) genes and is under the control of the Sxl gene. Recent genetic and molecular studies have suggested at the msl proteins may associate with one another in a sex-specific heteromeric complex on the male X chromosome, where they may function to alter its chromatin structure. |
| Document Type: Review |
| Language: English |
Addresses:
1. STANFORD UNIV, DEPT BIOL SCI, STANFORD, CA 94305 USA
2. STANFORD UNIV, DEPT DEV BIOL, STANFORD, CA 94305 USA |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Genetics & Heredity |
| IDS Number: PJ039 |
| ISSN: 0168-9525 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |