| | |  | | | | Record from Web of Science® | | | | | | |
| GENETIC DISSECTION OF COMPLEX TRAITS |
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| Author(s): LANDER ES, SCHORK NJ |
| Source: SCIENCE Volume: 265 Issue: 5181 Pages: 2037-2048 Published: SEP 30 1994 |
| Times Cited: 2,033 References: 271 |
| Abstract: Medical genetics was revolutionized during the 1980s by the application of genetic mapping to locate the genes responsible for simple Mendelian diseases. Most diseases and traits, however, do not follow simple inheritance patterns. Geneticists have thus begun taking up the even greater challenge of the genetic dissection of complex traits. Four major approaches have been developed: linkage analysis, allele-sharing methods, association studies, and polygenic analysis of experimental crosses. This article synthesizes the current state of the genetic dissection of complex traits-describing the methods, limitations, and recent applications to biological problems. |
| Document Type: Review |
| Language: English |
| Reprint Address: LANDER, ES (reprint author), WHITEHEAD INST BIOMED RES, 9 CAMBRIDGE CTR, CAMBRIDGE, MA 02142 USA |
Addresses:
1. MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA
2. CASE WESTERN RESERVE UNIV, SCH MED, CTR HUMAN GENET, CLEVELAND, OH 44106 USA
3. CASE WESTERN RESERVE UNIV, SCH MED, DEPT GENET, CLEVELAND, OH 44106 USA
4. CASE WESTERN RESERVE UNIV HOSP, CLEVELAND, OH 44106 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PJ912 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |