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| INCREASED VASCULAR ENDOTHELIAL GROWTH-FACTOR LEVELS IN THE VITREOUS OF EYES WITH PROLIFERATIVE DIABETIC-RETINOPATHY |
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| Author(s): ADAMIS AP, MILLER JW, BERNAL MT, DAMICO DJ, FOLKMAN J, YEO TK, YEO KT |
| Source: AMERICAN JOURNAL OF OPHTHALMOLOGY Volume: 118 Issue: 4 Pages: 445-450 Published: OCT 1994 |
| Times Cited: 567 References: 25 |
| Abstract: The vitreous levels of the angiogenic polypeptide vascular endothelial growth factor (also known as vascular permeability factor) were measured and compared in eyes with and without proliferative diabetic retinopathy. Undiluted vitreous samples from 20 eyes were collected at the time of vitrectomy, and vascular endothelial growth factor levels were determined by using a time-resolved immunofluorometric assay. Vitreous vascular endothelial growth factor levels were significantly higher in eyes with proliferative diabetic retinopathy than in eyes without proliferative diabetic retinopathy (P = .006; Wilcoxon Rank Sum Test). The median vitreous concentration in the eyes with proliferative diabetic retinopathy was 29.1 pM and exceeded the known concentration required for the maximal proliferation of vascular endothelial cells in vitro. These data are consistent with vascular endothelial growth factor serving as a physiologically relevant angiogenic factor in proliferative diabetic retinopathy. |
| Document Type: Article |
| Language: English |
| Reprint Address: ADAMIS, AP (reprint author), MASSACHUSETTS EYE & EAR INFIRM, DEPT OPHTHALMOL, 243 CHARLES ST, BOSTON, MA 02114 USA |
Addresses:
1. CHILDRENS HOSP, DEPT SURG, BOSTON, MA 02115 USA
2. BETH ISRAEL HOSP, DEPT PATHOL, BOSTON, MA 02215 USA
3. HARVARD UNIV, SCH MED, BOSTON, MA USA |
| Publisher: OPHTHALMIC PUBL CO, 77 WEST WACKER DR, STE 660, CHICAGO, IL 60601 |
| Subject Category: Ophthalmology |
| IDS Number: PK509 |
| ISSN: 0002-9394 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |