| CYSTIC-FIBROSIS HETEROZYGOTE RESISTANCE TO CHOLERA-TOXIN IN THE CYSTIC-FIBROSIS MOUSE MODEL |
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| Author(s): GABRIEL SE, BRIGMAN KN, KOLLER BH, BOUCHER RC, STUTTS MJ |
| Source: SCIENCE Volume: 266 Issue: 5182 Pages: 107-109 Published: OCT 7 1994 |
| Times Cited: 226 References: 36 |
| Abstract: The effect of the number of cystic fibrosis (CF) alleles on cholera toxin (CT)-induced intestinal secretion was examined in the CF mouse model. CF mice that expressed no CF transmembrane conductance regulator (CFTR) protein did not secrete fluid in response to CT. Heterozygotes expressed 50 percent of the normal amount of CFTR protein in the intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion in response to CT. This correlation between CFTR protein and CT-induced chloride ion and fluid secretion suggests that CF heterozygotes might possess a selective advantage of resistance to cholera. |
| Document Type: Article |
| Language: English |
| Reprint Address: GABRIEL, SE (reprint author), UNIV N CAROLINA, DEPT MED, CHAPEL HILL, NC 27599 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PK582 |
| ISSN: 0036-8075 |