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| DEFICIENT LONG-TERM-MEMORY IN MICE WITH A TARGETED MUTATION OF THE CAMP-RESPONSIVE ELEMENT-BINDING PROTEIN |
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| Author(s): BOURTCHULADZE R, FRENGUELLI B, BLENDY J, CIOFFI D, SCHUTZ G, SILVA AJ |
| Source: CELL Volume: 79 Issue: 1 Pages: 59-68 Published: OCT 7 1994 |
| Times Cited: 911 References: 38 |
| Abstract: The cAMP-responsive element-binding protein (CREB) has been implicated in the activation of protein synthesis required for long-term facilitation, a cellular model of memory in Aplysia. Our studies with fear conditioning and with the water maze show that mice with a targeted disruption of the alpha and delta isoforms of CREB are profoundly deficient in long-term memory. In contrast, short-term memory, lasting between 30 and 60 min, is normal. Consistent with models claiming a role for long-term potentiation (LTP) in memory, LTP in hippocampal slices from CREB mutants decayed to baseline 90 min after tetanic stimulation. However, paired-pulse facilitation and posttetanic potentiation are normal. These results implicate CREB-dependent transcription in mammalian long-term memory. |
| Document Type: Article |
| Language: English |
| Reprint Address: BOURTCHULADZE, R (reprint author), COLD SPRING HARBOR LAB, COLD SPRING HARBOR, NY 11724 USA |
Addresses:
1. UNIV HEIDELBERG, GERMAN CANC RES CTR, D-69120 HEIDELBERG, GERMANY |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: PK585 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |