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| ACTIVIN SIGNALING AND RESPONSE TO A MORPHOGEN GRADIENT |
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| Author(s): GURDON JB, HARGER P, MITCHELL A, LEMAIRE P |
| Source: NATURE Volume: 371 Issue: 6497 Pages: 487-492 Published: OCT 6 1994 |
| Times Cited: 245 References: 47 |
| Abstract: Using combinations of amphibian embryo tissues, it is shown that the selection of genes expressed by a cell is determined by its distance from a source of activin, a peptide growth factor contained in vegetal cells and able to induce other cells to form mesoderm. This long-range signal spreads over at least 10 cell diameters In a few hours. It does so by passive diffusion, because It can by-pass cells that do not themselves respond to the signal nor synthesize protein. These results provide direct support for the operation of a morphogen concentration gradient In vertebrate development. |
| Document Type: Article |
| Language: English |
| Reprint Address: GURDON, JB (reprint author), WELLCOME CRC INST, TENNIS COURT RD, CAMBRIDGE CB2 1QR, ENGLAND |
Addresses:
1. UNIV CAMBRIDGE, DEPT ZOOL, CAMBRIDGE CB2 3EJ, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PK589 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |