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| SELF-REPLICATING MOLECULES - A 2ND GENERATION |
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| Author(s): WINTNER EA, CONN MM, REBEK J |
| Source: JOURNAL OF THE AMERICAN CHEMICAL SOCIETY Volume: 116 Issue: 20 Pages: 8877-8884 Published: OCT 5 1994 |
| Times Cited: 44 References: 34 |
| Abstract: The use of self-complementary structures in replication experiments is discussed, and a second generation of self-replicating molecules is introduced. Key design elements of the new system are described, specifically a high affinity (K-a similar to 10(5) M(-1) in CDCl3) between the two complementary reactive components and the careful placement of nucleophilic and electrophilic centers within the system. These considerations preclude intramolecular reactions within two-component complexes, thus minimizing undesirable background reactions. Autocatalysis is observed in the new systems, and by using appropriate control experiments the autocatalysis is traced to template effects. |
| Document Type: Article |
| Language: English |
Addresses:
1. MIT, DEPT CHEM, CAMBRIDGE, MA 02139 USA |
| Publisher: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 |
| Subject Category: Chemistry, Multidisciplinary |
| IDS Number: PK979 |
| ISSN: 0002-7863 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |