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| ACCUMULATION OF TC-99M-GLUTATHIONE IN HEAD AND NECK TUMORS |
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| Author(s): ERCAN MT, ARAS T, AKTAS A, KAYA S, BEKDIK CF |
| Source: NUKLEARMEDIZIN Volume: 33 Issue: 5 Pages: 224-228 Published: OCT 1994 |
| Times Cited: 6 References: 23 |
| Abstract: Glutathione labelled with Tc-99m was used to study blood clearance and normal distribution in 3 healthy volunteers and in 10 patients with biopsy-proven tumors in the head and neck region. Static scintigrams were obtained at 1, 3, 6, and 24 h. ROls over tumors and normal soft tissues were compared to obtain T/N ratios. In normal subjects blood clearance reached a plateau at 6 h; no radioactivity accumulation in the head and neck region was observed. Only the cardiac blood pool, the liver, the kidneys and the urinary bladder were evident. Excretion was via the kidneys. Malignant tumors and metastases were well visualized in 7 patients (true-positive), starting at 1 h. The mean T/N ratio was 2.69 +/- 0.77. The best images were obtained at 3-6 h. 1 false-positive (granulamatous reaction), 1 false-negative (malignant epithelial tumor in the radix of tongue) and 1 true-negative (angiofibroma) results were obtained. Tc-99m-GSH is a potential radiopharmaceutical for the scintigraphic visualization of head and neck tumors. Further clinical studies are warranted to show its sensitivity and accuracy. |
| Document Type: Article |
| Language: English |
| Reprint Address: ERCAN, MT (reprint author), HACETTEPE UNIV, FAC MED, DEPT NUCL MED, ANKARA 06106, TURKEY |
Addresses:
1. HACETTEPE UNIV, FAC MED, DEPT OTORHINOLARYNGOL, ANKARA, TURKEY |
| Publisher: F K SCHATTAUER VERLAG GMBH, P O BOX 10 45 45, LENZHALDE 3, D-70040 STUTTGART, GERMANY |
| Subject Category: Radiology, Nuclear Medicine & Medical Imaging |
| IDS Number: PM145 |
| ISSN: 0029-5566 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |