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| LONG-TERM RESPONSES OF WOMEN TO INDOLE-3-CARBINOL OR A HIGH-FIBER DIET |
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| Author(s): BRADLOW HL, MICHNOVICZ JJ, HALPER M, MILLER DG, WONG GYC, OSBORNE MP |
| Source: CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION Volume: 3 Issue: 7 Pages: 591-595 Published: OCT-NOV 1994 |
| Times Cited: 81 References: 20 |
| Abstract: We test the hypothesis that the estrogen metabolite ratio 2-OH-estrone:estriol can be raised via dietary indole-3-carbinol (13C) and that this higher ratio can be sustained over a 3-month test period. We also explore the possible role. of pure fiber on estradiol metabolism. Using a randomized clinical trial with three arms, each containing 20 subjects, arm 1 received 400 mg/day of 13C daily for 3 months, arm 2 received 20 g of alpha-cellulose daily for the same time period as a source of added fiber, and arm 3 received a placebo dose. Blood levels of a variety of biochemical parameters were measured. The urinary 2-OH-estrone:estriol estrogen metabolite ratio was measured monthly at the same time of the menstrual cycle. While no changes were observed in the control and alpha-cellulose-treated arms, a substantial mean increase in the ratio was observed in the 13C-treated arm at month 1; that increase was maintained over the 3-month time period. Three of the 20 subjects in this 13C-treated group differed from the others in that no significant change in the metabolite ratio was observed at any time point. The results suggest that 13C can serve to increase the 2-OH-estrone:estriol metabolite ratio in a sustained manner without detectable side effects and that some individuals may be resistant to such change. |
| Document Type: Article |
| Language: English |
Addresses:
1. INST HORMONE RES, NEW YORK, NY 10021 USA
2. STRANG CANC PREVENT CTR, NEW YORK, NY 10021 USA |
| Publisher: AMER ASSOC CANCER RESEARCH, PUBLIC LEDGER BLDG, SUITE 816, 150 S. INDEPENDENCE MALL W., PHILADELPHIA, PA 19106 |
| Subject Category: Oncology; Public, Environmental & Occupational Health |
| IDS Number: PM725 |
| ISSN: 1055-9965 |
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