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| GENERATION AND IN-VIVO PERSISTENCE OF POLARIZED TH1 AND TH2 MEMORY CELLS |
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| Author(s): SWAIN SL |
| Source: IMMUNITY Volume: 1 Issue: 7 Pages: 543-552 Published: OCT 1994 |
| Times Cited: 233 References: 49 |
| Abstract: In vitro generated CD4 cell lines and effecters often produce either Th1 or Th2 cytokines, but stimulation of resting CD4 cells from animals leads to production mostly of IL-2. To determine whether polarization of CD4 effector cells results in development of polarized memory, I generated antigen-specific Th1 and Th2 effecters in vitro and transferred them to adoptive hosts. The effecters gave rise to long-lived populations of CD4 T cells with the phenotype of resting memory cells. Recovered cells responded vigorously to specific antigen, producing a pattern of cytokines closely related to that of the transferred effecters. Thus, encounter with a peptide antigen and directive cytokines at the initiation of culture can lead to generation of both effector and long-lived memory cell populations that produce restricted patterns of cytokines. |
| Document Type: Article |
| Language: English |
| Reprint Address: SWAIN, SL (reprint author), UNIV CALIF SAN DIEGO, DEPT BIOL, LA JOLLA, CA 92093 USA |
Addresses:
1. UNIV CALIF SAN DIEGO, CTR CANC, LA JOLLA, CA 92093 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Immunology |
| IDS Number: PN127 |
| ISSN: 1074-7613 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |