| | |  | | | | Record from Web of Science® | | | | | | |
| VERTEBRATE EMBRYONIC INDUCTION - MESODERMAL AND NEURAL PATTERNING |
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| Author(s): KESSLER DS, MELTON DA |
| Source: SCIENCE Volume: 266 Issue: 5185 Pages: 596-604 Published: OCT 28 1994 |
| Times Cited: 267 References: 218 |
| Abstract: Within the fertilized egg lies the information necessary to generate a diversity of cell types in the precise pattern of tissues and organs that comprises the vertebrate body. Seminal embryological experiments established the importance of induction, or cell interactions, in the formation of embryonic tissues and provided a foundation for molecular studies. In recent years, secreted gene products capable of inducing or patterning embryonic tissues have been identified. Despite these advances, embryologists remain challenged by fundamental questions: What are the endogenous inducing molecules? How is the action of an inducer spatially and temporally restricted? How does a limited group of inducers give rise to a diversity of tissues? In this review, the focus is on the induction and patterning of mesodermal and neural tissues in the frog Xenopus laevis, with an emphasis on families of secreted molecules that appear to underlie inductive events throughout vertebrate embryogenesis. |
| Document Type: Review |
| Language: English |
| Reprint Address: KESSLER, DS (reprint author), HARVARD UNIV, HOWARD HUGHES MED INST, DEPT MOLEC & CELLULAR BIOL, CAMBRIDGE, MA 02138 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PN807 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |