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| P53 STATUS AND THE EFFICACY OF CANCER-THERAPY IN-VIVO |
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| Author(s): LOWE SW, BODIS S, MCCLATCHEY A, REMINGTON L, RULEY HE, FISHER DE, HOUSMAN DE, JACKS T |
| Source: SCIENCE Volume: 266 Issue: 5186 Pages: 807-810 Published: NOV 4 1994 |
| Times Cited: 1,200 References: 25 |
| Abstract: The therapeutic responsiveness of genetically defined tumors expressing or devoid of the p53 tumor suppressor gene was compared in immunocompromised mice. Tumors expressing the p53 gene contained a high proportion of apoptotic cells and typically regressed after treatment with gamma radiation or adriamycin. In contrast, p53-deficient tumors treated with the same regimens continued to enlarge and contained few apoptotic cells. Acquired mutations in p53 were associated with both treatment resistance and relapse in p53-expressing tumors. These results establish that defects in apoptosis, here caused by the inactivation of p53, can produce treatment-resistant tumors and suggest that p53 status may be an important determinant of tumor response to therapy. |
| Document Type: Article |
| Language: English |
Addresses:
1. MIT, HOWARD HUGHES MED INST, CAMBRIDGE, MA 02139 USA
2. MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA
3. HARVARD UNIV, SCH MED, JOINT CTR RADIAT THERAPY, BOSTON, MA 02115 USA
4. HARVARD UNIV, SCH MED, DANA FARBER CANC INST, BOSTON, MA 02115 USA
5. VANDERBILT UNIV, SCH MED, DEPT IMMUNOL & MICROBIOL, NASHVILLE, TN 37232 USA
6. HARVARD UNIV, CHILDRENS HOSP, SCH MED, BOSTON, MA 02115 USA
7. MIT, CTR CANC RES, CAMBRIDGE, MA 02139 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PP753 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |