| | |  | | | | Record from Web of Science® | | | | | | |
| MECHANISM OF INTRACELLULAR PROTEIN-TRANSPORT |
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| Author(s): ROTHMAN JE |
| Source: NATURE Volume: 372 Issue: 6501 Pages: 55-63 Published: NOV 3 1994 |
| Times Cited: 1,763 References: 126 |
| Abstract: Recent advances have uncovered the general protein apparatus used by all eukaryotes for intracellular transport, including secretion and endocytosis, and for triggered exocytosis of hormones and neurotransmitters. Membranes are shaped into vesicles by cytoplasmic coats which then dissociate upon GTP hydrolysis. Both vesicles and their acceptor membranes carry targeting. proteins which interact specifically to initiate docking. A general apparatus then assembles at the docking site and fuses the vesicle with its target. |
| Document Type: Review |
| Language: English |
| Reprint Address: ROTHMAN, JE (reprint author), MEM SLOAN KETTERING CANC CTR, CELLULAR BIOCHEM & BIOPHYS PROGRAM, 1275 YORK AVE, NEW YORK, NY 10021 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PQ348 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |