| | |  | | | | Record from Web of Science® | | | | | | |
| CHROMOSOMAL TRANSLOCATIONS IN HUMAN CANCER |
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| Author(s): RABBITTS TH |
| Source: NATURE Volume: 372 Issue: 6502 Pages: 143-149 Published: NOV 10 1994 |
| Times Cited: 1,165 References: 100 |
| Abstract: Chromosomal abnormalities in tumours were recognized at the end of the last century but their significance has only recently become clear. Distinct translocations in leukaemias and in solid tumours lead to the activation of proto-oncogene products or, more commonly, creation of tumour-specific fusion proteins. The proteins in both categories are often transcription factors and thus disruption of transcriptional control plays a major role in the aetiology of cancer. Fusion proteins formed after chromosomal translocations are common in a range of tumour types; these are unique tumour antigens and are therefore potential targets for therapy design. |
| Document Type: Review |
| Language: English |
| Reprint Address: RABBITTS, TH (reprint author), MRC, MOLEC BIOL LAB, HILLS RD, CAMBRIDGE CB2 2QH, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PQ688 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |