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| OXIDATIVE STRESS IN HEMODIALYSIS |
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| Author(s): LOUGHREY CM, YOUNG IS, LIGHTBODY JH, MCMASTER D, MCNAMEE PT, TRIMBLE ER |
| Source: QUARTERLY JOURNAL OF MEDICINE Volume: 87 Issue: 11 Pages: 679-683 Published: NOV 1994 |
| Times Cited: 193 References: 24 |
| Abstract: Patients with chronic renal failure, including those receiving regular long-term haemodialysis, have a high incidence of premature cardiovascular disease. Oxidative stress, which occurs when there is excessive free-radical production or low antioxidant levels, has recently been implicated as a causative factor in atherogenesis. The aim of this study was to determine if chronic renal failure and haemodialysis were associated with increased oxidative stress. Serum malondialdehyde was measured as a marker of lipid peroxidation in 15 patients with conservatively managed chronic renal failure (CRF), 15 patients with CRF undergoing regular haemodialysis and 15 healthy controls. Selenium, glutathione peroxidase and antioxidant vitamins were also measured. Malondialdehyde was elevated in dialysis patients in comparison to CRF and control groups (dialysis 1.16 +/- 0.08 mu mol/l, CRF 0.94 +/- 0.07, controls 0.66 +/- 0.10). Antioxidants, including vitamin C, selenium and glutathione peroxidase, were decreased in dialysis patients and to a lesser extent in the CRF group (vitamin C-dialysis 16.43 +/- 3.76 mu mol/l, CRF 34.5 +/- 8.6, controls 56.11 +/- 7.41; selenium-dialysis 0.77 +/- 0.07 mu mol/l, CRF 0.69 +/- 0.06, controls 1.09 +/- 0.06: glutathione peroxidase-dialysis 101 +/- 5 U/l, CRF 160 +/- 11, controls 290 +/- 10). These findings indicate oxidative stress in patients with CRF which is further exacerbated by haemodialysis, as evidenced by increased lipid peroxidation and low antioxidant levels. This stress may play a role in the development of atherosclerosis in these groups. |
| Document Type: Article |
| Language: English |
Addresses:
1. BELFAST CITY HOSP, REG NEPHROL UNIT, BELFAST BT9 7AD, ANTRIM NORTH IRELAND
2. QUEENS UNIV BELFAST, DEPT MED, BELFAST, ANTRIM NORTH IRELAND
3. QUEENS UNIV BELFAST, DEPT CLIN BIOCHEM, BELFAST, ANTRIM NORTH IRELAND |
| Publisher: OXFORD UNIV PRESS UNITED KINGDOM, WALTON ST JOURNALS DEPT, OXFORD, ENGLAND OX2 6DP |
| Subject Category: Medicine, General & Internal |
| IDS Number: PQ857 |
| ISSN: 0033-5622 |
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