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| GDNF - A POTENT SURVIVAL FACTOR FOR MOTONEURONS PRESENT IN PERIPHERAL-NERVE AND MUSCLE |
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| Author(s): HENDERSON CE, PHILLIPS HS, POLLOCK RA, DAVIES AM, LEMEULLE C, ARMANINI M, SIMPSON LC, MOFFET B, VANDLEN RA, KOLIATSOS VE, ROSENTHAL A |
| Source: SCIENCE Volume: 266 Issue: 5187 Pages: 1062-1064 Published: NOV 11 1994 |
| Times Cited: 825 References: 29 |
| Abstract: For survival, embryonic motoneurons in vertebrates depend on as yet undefined neurotrophic factors present in the limb bud. Members of the neurotrophin family are currently the best candidates for such neurotrophic factors, but inactivation of their receptor genes leads to only partial loss of motoneurons, which suggests that other factors are involved. Glial cell line-derived neurotrophic factor (GDNF), originally identified as a trophic factor specific for dopaminergic neurons, was found to be 75-fold more potent than the neurotrophins in supporting the survival of purified embryonic rat motoneurons in culture. GDNF messenger RNA was found in the immediate vicinity of motoneurons during the period of cell death in development. In vivo, GDNF rescues and prevents the atrophy of facial motoneurons that have been deprived of target-derived survival factors by axotomy. GDNF may therefore be a physiological trophic factor for spinal motoneurons. Its potency and specificity in vitro and in vivo also make it a good candidate for treatment of motoneuron disease. |
| Document Type: Article |
| Language: English |
Addresses:
1. GENENTECH INC, DEPT NEUROSCI, S SAN FRANCISCO, CA 94080 USA
2. IBDM, INSERM, U382, F-13288 MARSEILLE 9, FRANCE
3. GENENTECH INC, DEPT PROT CHEM, S SAN FRANCISCO, CA 94080 USA
4. GENENTECH INC, DEPT CELL GENET, S SAN FRANCISCO, CA 94080 USA
5. SCH BIOL & MED SCI ST ANDREWS, ST ANDREWS, FIFE SCOTLAND
6. JOHNS HOPKINS UNIV, SCH MED, DEPT PATHOL NEUROL & NEUROSCI, BALTIMORE, MD 21205 USA
7. JOHNS HOPKINS UNIV, SCH MED, NEUROPATHOL LAB, BALTIMORE, MD 21205 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PQ924 |
| ISSN: 0036-8075 |
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