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| CRYSTAL-STRUCTURE OF A 4-STRANDED INTERCALATED DNA - D(C-4) |
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| Author(s): CHEN LQ, CAI L, ZHANG XH, RICH A |
| Source: BIOCHEMISTRY Volume: 33 Issue: 46 Pages: 13540-13546 Published: NOV 22 1994 |
| Times Cited: 106 References: 23 |
| Abstract: The crystal structure of d(C-4) solved at 2.3-Angstrom resolution reveals a four-stranded molecule composed of two interdigitated or intercalated duplexes. The duplexes are held together by hemiprotonated cytosine-cytosine base pairs and are parallel stranded, but the two duplexes point in opposite directions. The molecule has a slow right-handed twist of 12.4 degrees between covalently linked cytosine base pairs, and the base stacking distance is 3.1 Angstrom. This is in general agreement with the NMR studies. A biological role for DNA in this conformation is suggested. |
| Document Type: Article |
| Language: English |
| Reprint Address: CHEN, LQ (reprint author), MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA |
| Publisher: AMER CHEMICAL SOC, 1155 16TH ST, NW, WASHINGTON, DC 20036 |
| Subject Category: Biochemistry & Molecular Biology |
| IDS Number: PT485 |
| ISSN: 0006-2960 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |