| GENE INHIBITION USING ANTISENSE OLIGODEOXYNUCLEOTIDES |
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| Author(s): WAGNER RW |
| Source: NATURE Volume: 372 Issue: 6504 Pages: 333-335 Published: NOV 24 1994 |
| Times Cited: 731 References: 53 |
| Abstract: Antisense oligodeoxynucleotides (ODNs) have great promise as agents for the specific manipulation of gene expression. Until recently, nonspecific effects of ODNs often confounded the interpretation of antisense studies. Improvements in ODN chemistry and cellular delivery techniques now allow for more potent and specific gene inhibition. This review critically evaluates recent progress in the development of antisense ODNs. |
| Document Type: Article |
| Language: English |
| Reprint Address: WAGNER, RW (reprint author), GILEAD SCI, 353 LAKESIDE DR, FOSTER CITY, CA 94404 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PU287 |
| ISSN: 0028-0836 |