| | |  | | | | Record from Web of Science® | | | | | | |
| BLOCK OF GLUTAMATE TRANSPORTERS POTENTIATES POSTSYNAPTIC EXCITATION |
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| Author(s): TONG G, JAHR CE |
| Source: NEURON Volume: 13 Issue: 5 Pages: 1195-1203 Published: NOV 1994 |
| Times Cited: 249 References: 44 |
| Abstract: We have studied the effects of blockers of glutamate transporters on excitatory synaptic transmission to determine whether transporters increase the clearance rate of transmitter from the synaptic cleft on the millisecond time scale. The transporter blockers Li+ and THA increased the amplitude, but not the decay time, of spontaneous miniature AMPA receptor EPSCs recorded at 34 degrees C but not 24 degrees C. Evoked AMPA receptor EPSCs were similarly affected by THA. The rapidly dissociating AMPA receptor competitive antagonist PDA inhibited evoked AMPA receptor EPSCs less in the presence of THA at both temperatures, implying that transporter blockade slows clearance. We suggest that transporters speed glutamate clearance mainly by binding glutamate and that AMPA receptors are not saturated by synaptically released glutamate at 34 degrees C. |
| Document Type: Article |
| Language: English |
| Reprint Address: TONG, G (reprint author), OREGON HLTH SCI UNIV, VOLLUM INST, PORTLAND, OR 97201 USA |
Addresses:
1. OREGON HLTH SCI UNIV, DEPT CELL BIOL & ANAT, PORTLAND, OR 97201 USA |
| Publisher: CELL PRESS, 1050 MASSACHUSETTES AVE, CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: PU763 |
| ISSN: 0896-6273 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |