| | |  | | | | Record from Web of Science® | | | | | | |
| POSITIONAL CLONING OF THE MOUSE OBESE GENE AND ITS HUMAN HOMOLOG |
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| Author(s): ZHANG YY, PROENCA R, MAFFEI M, BARONE M, LEOPOLD L, FRIEDMAN JM |
| Source: NATURE Volume: 372 Issue: 6505 Pages: 425-432 Published: DEC 1 1994 |
| Times Cited: 6,031 References: 49 |
| Abstract: The mechanisms that balance food intake and energy expenditure determine who will be obese and who will be lean. One of the molecules that regulates energy balance in the mouse is the obese (ob) gene. Mutation of ob results in profound obesity and type II diabetes as part of a syndrome that resembles morbid obesity in humans. The ob gene product may function as part of a signalling pathway from adipose tissue that acts to regulate the size of the body fat depot. |
| Document Type: Article |
| Language: English |
Addresses:
1. HOWARD HUGHES MED INST, NEW YORK, NY 10021 USA
2. ROCKEFELLER UNIV, NEW YORK, NY 10021 USA |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PV012 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |