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| EXOCYTOSIS IN SPERMATOZOA IN RESPONSE TO PROGESTERONE AND ZONA-PELLUCIDA |
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| Author(s): ROLDAN ERS, MURASE T, SHI QX |
| Source: SCIENCE Volume: 266 Issue: 5190 Pages: 1578-1581 Published: DEC 2 1994 |
| Times Cited: 191 References: 37 |
| Abstract: Exocytosis in mammalian spermatozoa (the acrosome reaction) is a process essential for fertilization. Both progesterone and zona pellucida induce exocytosis in spermatozoa, which may encounter both during penetration of the oocyte's vestments. When mouse spermatozoa were exposed first to progesterone and then to zona pellucida, exocytosis was enhanced to a greater degree than that seen when the agonists were presented together or in the inverse order, which suggests that the steroid exerts a priming effect. Progesterone similarly primed the generation of intracellular messengers evoked by zona pellucida. The effects triggered by progesterone were mimicked by gamma-aminobutyric acid (GABA) and were blocked by bicuculline, which indicates that the steroid acts on a GABA(A) receptor. |
| Document Type: Article |
| Language: English |
| Reprint Address: ROLDAN, ERS (reprint author), BIOTECHNOL & BIOL SCI RES COUNCIL, BABRAHAM INST, DEPT DEV & SIGNALLING, CAMBRIDGE CB2 4AT, ENGLAND |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 USA |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PV015 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |