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| NATURALLY-OCCURRING VARIATION IN BRISTLE NUMBER AND DNA POLYMORPHISMS AT THE SCABROUS LOCUS OF DROSOPHILA-MELANOGASTER |
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| Author(s): LAI CG, LYMAN RF, LONG AD, LANGLEY CH, MACKAY TFC |
| Source: SCIENCE Volume: 266 Issue: 5191 Pages: 1697-1702 Published: DEC 9 1994 |
| Times Cited: 125 References: 33 |
| Abstract: The association between quantitative genetic variation in bristle number and molecular Variation at a candidate neurogenic locus, scabrous, was examined in Drosophila melanogaster. Approximately 32 percent of the genetic Variation in abdominal bristle number (21 percent for sternopleural bristle number) among 47 second chromosomes from a natural population was correlated with DNA sequence polymorphisms at this locus. Several polymorphic sites associated with large phenotypic effects occurred at intermediate frequency. Quantitative genetic variation in natural populations caused by alleles that have large effects at a few loci and that segregate at intermediate frequencies conflicts with the classical infinitesimal model of the genetic basis of quantitative variation. |
| Document Type: Article |
| Language: English |
| Reprint Address: LAI, CG (reprint author), UNIV CALIF DAVIS, CTR POPULAT BIOL, DAVIS, CA 95616 USA |
Addresses:
1. N CAROLINA STATE UNIV, DEPT GENET, RALEIGH, NC 27695 USA
2. MCMASTER UNIV, DEPT BIOL, HAMILTON L8S 4K1, ON CANADA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PW308 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |