| | |  | | | | Record from Web of Science® | | | | | | |
| PROTEIN SUPERFAMILIES AND DOMAIN SUPERFOLDS |
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| Author(s): ORENGO CA, JONES DT, THORNTON JM |
| Source: NATURE Volume: 372 Issue: 6507 Pages: 631-634 Published: DEC 15 1994 |
| Times Cited: 517 References: 27 |
| Abstract: As the protein sequence and structure databases expand rapidly a better understanding of the relationships between proteins is required. A classification is considered that extends the sequence-based superfamilies to include proteins with similar function and three-dimensional structures but no sequence similarity. So far there are only nine protein folds known to recur in proteins having neither sequence nor functional similarity. These folds dominate the structure database, representing more than 30 per cent of all determined structures. This observation has implications for protein-fold recognition. |
| Document Type: Article |
| Language: English |
| Reprint Address: ORENGO, CA (reprint author), UNIV LONDON UNIV COLL, DEPT BIOCHEM & MOLEC BIOL, BIOMOLEC STRUCT & MODELLING UNIT, GOWER ST, LONDON WC1E 6BT, ENGLAND |
Addresses:
1. NATL INST MED RES, MATH BIOL LAB, LONDON NW7 1AA, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, PORTERS SOUTH, 4 CRINAN ST, LONDON, ENGLAND N1 9XW |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PX307 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |