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| IDENTIFICATION OF HERPESVIRUS-LIKE DNA-SEQUENCES IN AIDS-ASSOCIATED KAPOSIS-SARCOMA |
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| Author(s): CHANG Y, CESARMAN E, PESSIN MS, LEE F, CULPEPPER J, KNOWLES DM, MOORE PS |
| Source: SCIENCE Volume: 266 Issue: 5192 Pages: 1865-1869 Published: DEC 16 1994 |
| Times Cited: 2,894 References: 30 |
| Abstract: Representational difference analysis was used lo isolate unique sequences present in more than 90 percent of Kaposi's sarcoma (KS) tissues obtained from patients with acquired immunodeficiency syndrome (AIDS). These sequences were not present in tissue DNA from non-AIDS patients, but were present in 15 percent of non-KS tissue DNA samples from AIDS patients. The sequences are homologous to, but distinct from, capsid and tegument protein genes of the Gammaherpesvirinae, herpesvirus saimiri and Epstein-Barr virus. These KS-associated herpesvirus-like (KSHV) sequences appear to define a new human herpesvirus. |
| Document Type: Article |
| Language: English |
| Reprint Address: CHANG, Y (reprint author), COLUMBIA UNIV, COLL PHYS & SURG, DEPT PATHOL, 630 W 168TH ST, NEW YORK, NY 10032 USA |
Addresses:
1. DNAX RES INST MOLEC & CELLULAR BIOL INC, DEPT BIOL MOLEC, PALO ALTO, CA 94304 USA
2. NEW YORK CITY DEPT HLTH, DIS INTERVENT COMMISS, NEW YORK, NY 10013 USA
3. COLUMBIA UNIV, SCH PUBL HLTH, DIV EPIDEMIOL, NEW YORK, NY 10013 USA |
| Publisher: AMER ASSOC ADVANCEMENT SCIENCE, 1200 NEW YORK AVE, NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PX383 |
| ISSN: 0036-8075 |
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