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| BAYESIAN APPROACHES TO RANDOMIZED TRIALS |
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| Author(s): SPIEGELHALTER DJ, FREEDMAN LS, PARMAR MKB |
| Source: JOURNAL OF THE ROYAL STATISTICAL SOCIETY SERIES A-STATISTICS IN SOCIETY Volume: 157 Pages: 357-387 Part: Part 3 Published: 1994 |
| Times Cited: 238 References: 69 |
| Abstract: Statistical issues in conducting randomized trials include the choice of a sample size, whether to stop a trial early and the appropriate analysis and interpretation of the trial results. At each of these stages, evidence external to the trial is useful, but generally such evidence is introduced in an unstructured and informal manner. We argue that a Bayesian approach allows a formal basis for using external evidence and in addition provides a rational way for dealing with issues such as the ethics of randomization, trials to show treatment equivalence, the monitoring of accumulating data and the prediction of the consequences of continuing a study. The motivation for using this methodology is practical rather than ideological. |
| Document Type: Article |
| Language: English |
| Reprint Address: SPIEGELHALTER, DJ (reprint author), INST PUBL HLTH, MRC, BIOSTAT UNIT, ROBINSON WAY, CAMBRIDGE CB2 2SR, ENGLAND |
Addresses:
1. MRC, CANC TRIALS OFF, CAMBRIDGE, ENGLAND
2. NCI, BETHESDA, MD 20892 USA |
| Publisher: BLACKWELL PUBL LTD, 108 COWLEY RD, OXFORD, OXON, ENGLAND OX4 1JF |
| Subject Category: Social Sciences, Mathematical Methods; Statistics & Probability |
| IDS Number: PX871 |
| ISSN: 0035-9238 |
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