| | |  | | | | Record from Web of Science® | | | | | | |
| IMMUNOHISTOCHEMICAL LOCALIZATION OF HYDROXYSTEROID SULFOTRANSFERASE IN HUMAN BREAST-CARCINOMA TISSUE - A PRELIMINARY-STUDY |
|
|
| Author(s): SHARP S, ANDERSON JM, COUGHTRIE MWH |
| Source: EUROPEAN JOURNAL OF CANCER Volume: 30A Issue: 11 Pages: 1654-1659 Published: 1994 |
| Times Cited: 16 References: 21 |
| Abstract: Understanding the function and regulation of the metabolism of steroid hormones by breast tumours will be instrumental to the development of novel treatments for this widespread disease. We have examined the expression of hydroxysteroid sulphotransferase, an enzyme which inactivates many steroids, in particular androgens, in normal breast tissue and in six ductal-type mammary carcinomas using immunohistochemistry. The enzyme is not expressed in the epithelial cells which line the normal breast duct, but is present in significant amounts in neoplastic cells, suggesting that the gene encoding this protein is activated at some stage of the neoplastic transformation. The implications of this finding for the role of steroid metabolism in breast cancer are discussed. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT BIOCHEM MED, DUNDEE DD1 9SY, SCOTLAND
2. UNIV DUNDEE, NINEWELLS HOSP & MED SCH, DEPT PATHOL, DUNDEE DD1 9SY, SCOTLAND |
| Publisher: PERGAMON-ELSEVIER SCIENCE LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, ENGLAND OX5 1GB |
| Subject Category: Oncology |
| IDS Number: PY646 |
| ISSN: 0959-8049 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |