| | |  | | | | Record from Web of Science® | | | | | | |
| SPECIFIC ASSOCIATION OF HUMAN TELOMERASE ACTIVITY WITH IMMORTAL CELLS AND CANCER |
|
|
| Author(s): KIM NW, PIATYSZEK MA, PROWSE KR, HARLEY CB, WEST MD, HO PLC, COVIELLO GM, WRIGHT WE, WEINRICH SL, SHAY JW |
| Source: SCIENCE Volume: 266 Issue: 5193 Pages: 2011-2015 Published: DEC 23 1994 |
| Times Cited: 3,843 References: 32 |
| Abstract: Synthesis of DNA at chromosome ends by telomerase may be necessary for indefinite proliferation of human cells. A highly sensitive assay for measuring telomerase activity was developed. In cultured cells representing 18 different human tissues, 98 of 100 immortal and none of 22 mortal populations were positive for telomerase. Similarly, 90 of 101 biopsies representing 12 human tumor types and none of 50 normal somatic tissues were positive. Normal ovaries and testes were positive, but benign tumors such as fibroids were negative. Thus, telomerase appears to be stringently repressed in normal human somatic tissues but reactivated in cancer, where immortal cells are likely required to maintain tumor growth. |
| Document Type: Article |
| Language: English |
Addresses:
1. GERON CORP, MENLO PK, CA 94025 USA
2. UNIV TEXAS, SW MED CTR, DEPT CELL BIOL & NEUROSCI, DALLAS, TX 75235 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: PZ267 |
| ISSN: 0036-8075 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |