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| INTRARECTAL INOCULATION OF MACAQUES BY THE SIMIAN IMMUNODEFICIENCY VIRUS, SIVMNE E11S - CD4+ DEPLETION AND AIDS |
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| Author(s): KULLER L, BENVENISTE RE, TSAI CC, CLARK EA, POLACINO P, WATANABE R, OVERBAUGH J, KATZE MG, MORTON WR |
| Source: JOURNAL OF MEDICAL PRIMATOLOGY Volume: 23 Issue: 7 Pages: 397-409 Published: SEP 1994 |
| Times Cited: 22 References: 42 |
| Abstract: Macaca nemestrina and Macaca fascicularis were inoculated with various doses of a single-cell clone of SIVmne-infected HuT 78 cells (E11S) by both the intravenous and intrarectal routes. Animals inoculated intravenously at each dose seroconverted and virus was isolated from peripheral blood mononuclear cells, but only the high-dose intrarectally exposed macaques became viremic and seroconverted. However, some seronegative, virus isolation negative intrarectally inoculated macaques showed evidence of infection and disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: KULLER, L (reprint author), UNIV WASHINGTON, REG PRIMATE RES CTR, SJ-50, SEATTLE, WA 98195 USA |
Addresses:
1. UNIV WASHINGTON, DEPT MICROBIOL, SEATTLE, WA 98195 USA
2. NCI, VIRAL CARCINOGENESIS LAB, FREDERICK, MD USA |
| Publisher: MUNKSGAARD INT PUBL LTD, 35 NORRE SOGADE, PO BOX 2148, DK-1016 COPENHAGEN, DENMARK |
| Subject Category: Veterinary Sciences; Zoology |
| IDS Number: QE407 |
| ISSN: 0047-2565 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |