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| EPIDEMIOLOGIC AND GENETIC-STUDIES OF CONGENITAL PROFOUND DEAFNESS IN THE GENERAL-POPULATION OF SICHUAN, CHINA |
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| Author(s): LIU XZ, XU LR, ZHANG SL, XU Y |
| Source: AMERICAN JOURNAL OF MEDICAL GENETICS Volume: 53 Issue: 2 Pages: 192-195 Published: NOV 1 1994 |
| Times Cited: 7 References: 15 |
| Abstract: People with congenital profound deafness (CPD) were surveyed in the general population of Sichuan. The prevalence was 0.082% (104/126, 876) of the general population, male 0.086%, female 0.078%. There was no significant difference in prevalence between urban and rural populations. However, the population living in the mountains had a much higher prevalence than people from the foothills and plains (P < 0.05). Amongst the nationalities investigated, there were significant differences in prevalence. Non-Chinese, except for Tibetans, presented a significantly higher prevalence than Han Chinese. There was a significantly higher prevalence among the inbred population (0.82%) than among the non-inbred population (0.072%). An effect of parental age was demonstrated, but no effect of birth order was found. There was a significant seasonal variation in prevalence. Inherited cases could account for 71.2% of all cases, of which 92% were autosomal recessive (AR) and 8% autosomal dominant (AD). Heterogeneity in AR was found with at least 8 different loci. The fitness was 60.26%, the coefficient of selection was 0.3974, mutation rate was estimated to be 2.0 X 10(-4), and no heterozygote advantage was proven. (C) 1994 Wiley-Liss, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: LIU, XZ (reprint author), UNIV MANCHESTER, DEPT MED GENET, MANCHESTER M13 9PL, LANCS ENGLAND |
Addresses:
1. W CHINA UNIV MED SCI, DEPT OTOLARYNGOL, CHENGDU, PEOPLES R CHINA
2. SICHUAN FAMILY PLANNING RES INST, DEPT EPIDEMIOL SURVEY, CHENGDU, PEOPLES R CHINA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Genetics & Heredity |
| IDS Number: QF815 |
| ISSN: 0148-7299 |
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