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| VIRAL DYNAMICS IN HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION |
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| Author(s): WEI XP, GHOSH SK, TAYLOR ME, JOHNSON VA, EMINI EA, DEUTSCH P, LIFSON JD, BONHOEFFER S, NOWAK MA, HAHN BH, SAAG MS, SHAW GM |
| Source: NATURE Volume: 373 Issue: 6510 Pages: 117-122 Published: JAN 12 1995 |
| Times Cited: 2,339 References: 44 |
| Abstract: The dynamics of HIV-1 replication in vivo are largely unknown yet they are critical to our understanding of disease pathogenesis. Experimental drugs that are potent inhibitors of viral replication can be used to show that the composite lifespan of plasma virus and virus-producing cells is remarkably short (half-life similar to 2 days). Almost complete replacement of wild-type virus in plasma by drug-resistant variants occurs after fourteen days, indicating that HIV-1 viraemia is sustained primarily by a dynamic process involving continuous rounds of de novo virus infection and replication and rapid cell turnover. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV ALABAMA, DIV HEMATOL ONCOL, BIRMINGHAM, AL 35294 USA
2. UNIV ALABAMA, DIV INFECT DIS, BIRMINGHAM, AL 35294 USA
3. MERCK SHARP & DOHME LTD, RES LABS, DEPT ANTIVIRAL RES, W POINT, PA 19486 USA
4. MERCK SHARP & DOHME LTD, RES LABS, DEPT CLIN PHARMACOL, W POINT, PA 19486 USA
5. GENELABS TECHNOL INC, DIV HIV & EXPLORATORY RES, REDWOOD CITY, CA 94063 USA
6. UNIV OXFORD, DEPT ZOOL, OXFORD OX1 3PS, ENGLAND |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QB063 |
| ISSN: 0028-0836 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |