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| REQUIREMENT OF FGF-4 FOR POSTIMPLANTATION MOUSE DEVELOPMENT |
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| Author(s): FELDMAN B, POUEYMIROU W, PAPAIOANNOU VE, DECHIARA TM, GOLDFARB M |
| Source: SCIENCE Volume: 267 Issue: 5195 Pages: 246-249 Published: JAN 13 1995 |
| Times Cited: 363 References: 36 |
| Abstract: Fibroblast growth factors (FGFs) are thought to influence many processes in vertebrate development because of their diverse sites of expression and wide range of biological activities in in vitro culture systems. As a means of elucidating embryonic functions of FGF-4, gene targeting was used to generate mice harboring a disrupted Fgf4 gene. Embryos homozygous for the null allele underwent uterine implantation and induced uterine decidualization but did not develop substantially thereafter. As was consistent with their behavior in vivo, Fgf4 null embryos cultured in vitro displayed severely impaired proliferation of the inner cell mass, whereas growth and differentiation of the inner cell mass were rescued when null embryos were cultured in the presence of FGF-4 protein. |
| Document Type: Article |
| Language: English |
Addresses:
1. REGENERON PHARMACEUT INC, TARRYTOWN, NY 10591 USA
2. COLUMBIA UNIV, COLL PHYS & SURG, INTEGRATED PROGRAM CELLULAR MOLEC & BIOPHYS STUDI, NEW YORK, NY 10032 USA
3. COLUMBIA UNIV, COLL PHYS & SURG, DEPT GENET & DEV, NEW YORK, NY 10032 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QB153 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |