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| STEM-CELL PATTERNING AND FATE IN HUMAN EPIDERMIS |
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| Author(s): JONES PH, HARPER S, WATT FM |
| Source: CELL Volume: 80 Issue: 1 Pages: 83-93 Published: JAN 13 1995 |
| Times Cited: 449 References: 38 |
| Abstract: Within human epidermis there are two types of proliferating keratinocyte: stem cells, which have high proliferative potential, and transit-amplifying cells, which are destined to undergo terminal differentiation after a few rounds of division. We show that, in vivo, stem cells express higher levels of the alpha(2) beta(1) and alpha(3) beta(1) integrins than transit-amplifying cells and that this can be used both to determine the location of stem cells within the epidermis and to isolate them directly from the tissue. The distribution of stem cells and transit-amplifying cells is not random: patches of integrin-bright and integrin-dull cells have a specific location with respect to the epidermal-dermal junction that varies between body sites and that correlates with the distribution of S phase cells. Stem cell patterning can be recreated in culture, in the absence of dermis, and appears to be subject to autoregulation. |
| Document Type: Article |
| Language: English |
Addresses:
1. IMPERIAL CANC RES FUND, KERATINOCYTE LAB, LONDON WC2A 3PX, ENGLAND
2. LEICESTER GEN HOSP, DEPT NEPHROL, LEICESTER LE5 4PW, LEICS ENGLAND |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: QB910 |
| ISSN: 0092-8674 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |