| | |  | | | | Record from Web of Science® | | | | | | |
| FAS AND FAS LIGAND - LPR AND GLD MUTATIONS |
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| Author(s): NAGATA S, SUDA T |
| Source: IMMUNOLOGY TODAY Volume: 16 Issue: 1 Pages: 39-43 Published: JAN 1995 |
| Times Cited: 695 References: 46 |
| Abstract: Fas ligand (FasL) is a death factor that binds to its receptor, Fas, and induces apoptosis. Two mutations that accelerate autoimmune disease, lpr and gld, are known to correspond to mutations within genes encoding Fas and Fast, respectively. Here, Shigekazu Nagata and Takashi Suda summarize current knowledge of Fas and Fast, and discuss the physiological role of the Fas system in T-cell development, cytotoxicity and cytotoxic T lymphocyte (CTL)-mediated autoimmune disease. |
| Document Type: Review |
| Language: English |
| Reprint Address: NAGATA, S (reprint author), OSAKA BIOSCI INST, 6-2-4 FURUEDAI, SUITA, OSAKA 565 JAPAN |
| Publisher: ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD, OXON, ENGLAND OX5 1GB |
| Subject Category: Immunology |
| IDS Number: QC229 |
| ISSN: 0167-5699 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |