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| TARGETED DISRUPTION OF THE P50 SUBUNIT OF NF-KAPPA-B LEADS TO MULTIFOCAL DEFECTS IN IMMUNE-RESPONSES |
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| Author(s): SHA WC, LIOU HC, TUOMANEN EI, BALTIMORE D |
| Source: CELL Volume: 80 Issue: 2 Pages: 321-330 Published: JAN 27 1995 |
| Times Cited: 738 References: 38 |
| Abstract: NF-kappa B, a heterodimeric transcription factor composed of p50 and p65 subunits, can be activated in many cell types and is thought to regulate a wide variety of genes involved in immune function and development, Mice lacking the p50 subunit of NF-kappa B show no developmental abnormalities, but exhibit multifocal defects in immune responses involving B lymphocytes and nonspecific responses to infection. B cells do not proliferate in response to bacterial lipopolysaccharide and are defective in basal and specific antibody production. Mice lacking p50 are unable effectively to clear L. monocytogenes and are more susceptible to infection with S. pneumoniae, but are more resistant to infection with murine encephalomyocarditis virus. These data support the role of NF-kappa B as a vital transcription factor for both specific and nonspecific immune responses, but do not indicate a developmental role for the factor. |
| Document Type: Article |
| Language: English |
Addresses:
1. MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA
2. CORNELL UNIV, COLL MED, DEPT CELL BIOL, DIV ALLERGY & IMMUNOL, NEW YORK, NY 10021 USA
3. CORNELL UNIV, COLL MED, DEPT MED, DIV ALLERGY & IMMUNOL, NEW YORK, NY 10021 USA
4. ROCKEFELLER UNIV, MOLEC INFECT DIS LAB, NEW YORK, NY 10021 USA |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: QD924 |
| ISSN: 0092-8674 |
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