| 100 YEARS LOCK-AND-KEY CONCEPT - ARE PEPTIDE KEYS SHAPED AND GUIDED TO THEIR RECEPTORS BY THE TARGET-CELL MEMBRANE |
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| Author(s): SCHWYZER R |
| Source: BIOPOLYMERS Volume: 37 Issue: 1 Pages: 5-16 Published: 1995 |
| Times Cited: 85 References: 53 |
| Abstract: The ideas developed in the Membrane Compartments Theory which allow a quantitative prediction of receptor preference are discussed in terms of our present knowledge of opioid and neurokinin receptor structure. Furthermore, conformations of regulatory peptides interacting with artificial lipid membranes are compared with those of chemically constrained molecules thar react selectively with different receptor classes. Striking similarities in the topochemistry of molecules with similar activity were observed. The membrane-induced topomers were almost congruent with the artificial topomers that are selectively recognized by the same receptors. (C) 1994 John Wiley & Sons, Inc. |
| Document Type: Article |
| Language: English |
Addresses:
1. CLIN RES INST MONTREAL, SWISS FED INST TECHNOL, DEPT MOLEC BIOL & BIOPHYS, MONTREAL, PQ H2W 1R7 CANADA |
| Publisher: JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Biochemistry & Molecular Biology; Biophysics |
| IDS Number: QE915 |
| ISSN: 0006-3525 |