| | |  | | | | Record from Web of Science® | | | | | | |
| EXPRESSION OF RELB IS REQUIRED FOR THE DEVELOPMENT OF THYMIC MEDULLA AND DENDRITIC CELLS |
|
|
| Author(s): BURKLY L, HESSION C, OGATA L, REILLY C, MARCONI LA, OLSON D, TIZARD R, CATE R, LO D |
| Source: NATURE Volume: 373 Issue: 6514 Pages: 531-536 Published: FEB 9 1995 |
| Times Cited: 442 References: 29 |
| Abstract: DENDRITIC cells (DC) derived from bone marrow are critical in the function of the immune system, for they are the primary antigen-presenting cells in the activation of T-lymphocyte response. Their differentiation from precursor cells has not been defined at a molecular level, but recent studies have shown an association between expression of the relB subunit of the NF-kappa B complex(1-5) and the presence of DC in specific regions of normal unstimulated lymphoid tissues(4-6). Here we show that relB expression also correlates with differentiation of DC in autoimmune infiltrates in situ, and that a mutation disrupting the relB gene results in mice with impaired antigen-presenting cell function, and a syndrome of excess production of granulocytes and macrophages. Thymic UEA-1(+) medullary epithelial cells from normal mice show striking similarities to DC and, interestingly, these cells are also absent in relB mutant mice. Taken together, these results suggest that relB is critical in the coordinated activation of genes necessary for the differentiation of two unrelated but phenotypically similar cells (DC and thymic UEA-1(+) medullary epithelial cells) and is therefore a candidate for a gene determining lineage commitment in the immune system. |
| Document Type: Article |
| Language: English |
Addresses:
1. Scripps Res Inst, RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA
2. BIOGEN INC, CAMBRIDGE, MA 02142 USA |
| Publisher: MACMILLAN MAGAZINES LTD, 4 LITTLE ESSEX STREET, LONDON, ENGLAND WC2R 3LF |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QF724 |
| ISSN: 0028-0836 |
|
| | | | | | | | | Record from Web of Science® | | | | | | | | | |