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| DOMINANT AND DIFFERENTIAL DEPOSITION OF DISTINCT BETA-AMYLOID PEPTIDE SPECIES, A-BETA(N3(PE)), IN SENILE PLAQUES |
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| Author(s): SAIDO TC, IWATSUBO T, MANN DMA, SHIMADA H, IHARA Y, KAWASHIMA S |
| Source: NEURON Volume: 14 Issue: 2 Pages: 457-466 Published: FEB 1995 |
| Times Cited: 209 References: 32 |
| Abstract: We analyzed an amino-terminal modification of beta-amyloid (A beta) peptide in brain, using anti-A beta antibodies that distinguish distinct molecular species. Examination of cortical sections from 28 aged individuals with a wide range in senile plaque density revealed that a molecular species distinct from the standard A beta is deposited in the brain in a dominant and differential manner. This modified A beta peptide (A beta(N3(pE))) starts at the 3rd aminoterminal residue of the standard A beta, glutamate, converted to pyroglutamate through intramolecular dehydration, Because plaqules composed of A beta(N3(pE)) are present in equivalent or greater densities than those composed of standard A beta bearing the first aminoterminal residue (A beta(N1)) and because deposition of the former species appears to precede deposition of the Tatter, as confirmed with specimens from Down's syndrome patients, the processes involved in A beta(N3(pE)) production and retention may play an early and critical role in senile plaque formation. |
| Document Type: Article |
| Language: English |
| Reprint Address: SAIDO, TC (reprint author), TOKYO METROPOLITAN INST MED SCI, DEPT MOLEC BIOL, BUNKYO KU, TOKYO 113, JAPAN |
Addresses:
1. UNIV TOKYO, FAC PHARMACEUT SCI, DEPT NEUROPATHOL & NEUROSCI, BUNKYO KU, TOKYO 113, JAPAN
2. UNIV MANCHESTER, DEPT PATHOL SCI, MANCHESTER, LANCS ENGLAND
3. TOKYO MED COLL, DEPT PATHOL, SHINJUKU KU, TOKYO 160, JAPAN
4. UNIV TOKYO, INST BRAIN RES, DEPT NEUROPATHOL, BUNKYO KU, TOKYO, JAPAN |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Neurosciences |
| IDS Number: QH294 |
| ISSN: 0896-6273 |
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