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| NATURAL-HISTORY STUDY OF HEREDITARY MULTIPLE EXOSTOSES |
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| Author(s): WICKLUND CL, PAULI RM, JOHNSTON D, HECHT JT |
| Source: AMERICAN JOURNAL OF MEDICAL GENETICS Volume: 55 Issue: 1 Pages: 43-46 Published: JAN 2 1995 |
| Times Cited: 86 References: 23 |
| Abstract: Hereditary multiple exostosis (EXT) is an autosomal dominant disorder in which the clinical hallmark is the growth of bony protuberances from long bones and which can cause a variety of orthopedic deformities, This study sought to further delineate the natural history of EXT, In addition, since previous studies have suggested that there are deviations from Mendelian expectations in EXT, including incomplete penetrance and a skewed sex ratio, we attempted to confirm or refute these suggestions, Both portions of the study were carried out through retrospective review of 43 affected probands and 137 of their affected relatives, Data are presented concerning frequency and severity of complications of EXT including short stature, sequelae of exostoses, occurrence of malignant degeneration of exostoses, and problems in pregnancy and delivery of affected females, Only 2.8% of the total affected population had experienced exostosis-related malignancy, an estimate which is considerably less than earlier reports would suggest, Penetrance was 100%, There was an excess of males within the entire affected population (104:76) and within identified probands (28:15), However, the male to female ratio was unskewed in nuclear families (probands, affected sibs, and parents), The excess of males appears to be related to males having more severe and more frequent complications of EXT than having any primary genetic origin. (C) 1995 Wiley-Liss, Inc. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV TEXAS, SCH MED, TEXAS MED CTR, HOUSTON, TX 77225 USA
2. UNIV WISCONSIN, MADISON, WI USA
3. UNIV MED & DENT NEW JERSEY, COOPER HOSP, MED CTR, CAMDEN, NJ 08103 USA
4. UNIV TEXAS, HLTH SCI CTR, HOUSTON, TX USA |
| Publisher: WILEY-LISS, DIV JOHN WILEY & SONS INC 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Genetics & Heredity |
| IDS Number: QH450 |
| ISSN: 0148-7299 |
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