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| RADIATION INHIBITION OF MDX MOUSE MUSCLE REGENERATION - DOSE AND AGE FACTORS |
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| Author(s): QUINLAN JG, LYDEN SP, CAMBIER DM, JOHNSON SR, MICHAELS SE, DENMAN DL |
| Source: MUSCLE & NERVE Volume: 18 Issue: 2 Pages: 201-206 Published: FEB 1995 |
| Times Cited: 30 References: 24 |
| Abstract: A single hind limb was irradiated with 12, 18, 24, or 30 Gy in mdx and C57 mice aged 12, 21, or 42 days to determine regeneration inhibition dose-response curves in different aged dystrophic mice and to characterize radiation side-effects in normal mice. The anterior tibial muscle mass (8 weeks postirradiation) and percent central nucleated (i.e., regenerated) muscle fibers were measures of regeneration inhibition. Twenty-one-day-old mdx mice irradiated with 18 Gy had complete inhibition of muscle regeneration, but 30 Gy only partially blocked regeneration in mdx mice irradiated at 12 and 42 days in age. In working to produce a clinically relevant model for Duchenne dystrophy, it is crucial to regard mouse age as a major factor in determining radiation effects on mdx muscle regeneration. (C) 1995 John Wiley and Sons, Inc. |
| Document Type: Article |
| Language: English |
| Reprint Address: QUINLAN, JG (reprint author), UNIV CINCINNATI, DEPT NEUROL, ROOM 4010 MSB, 231 BETHESDA AVE, CINCINNATI, OH 45267 USA |
Addresses:
1. UNIV CINCINNATI, DEPT STAT & EPIDEMIOL, CINCINNATI, OH 45267 USA
2. UNIV CINCINNATI, DEPT RADIOL, CINCINNATI, OH 45267 USA
3. UNIV CINCINNATI, COLL MED, CINCINNATI, OH 45267 USA |
| Publisher: JOHN WILEY & SONS INC, 605 THIRD AVE, NEW YORK, NY 10158-0012 |
| Subject Category: Clinical Neurology; Neurosciences |
| IDS Number: QH673 |
| ISSN: 0148-639X |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |