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| I-KAPPA-B-BETA REGULATES THE PERSISTENT RESPONSE IN A BIPHASIC ACTIVATION OF NF-KAPPA-B |
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| Author(s): THOMPSON JE, PHILLIPS RJ, ERDJUMENTBROMAGE H, TEMPST P, GHOSH S |
| Source: CELL Volume: 80 Issue: 4 Pages: 573-582 Published: FEB 24 1995 |
| Times Cited: 585 References: 33 |
| Abstract: We have cloned the cDNA encoding I kappa B-beta, one of the two major I kappa B isoforms in mammalian cells. The recombinant I kappa B-beta protein interacts with equal affinity to p65 and c-Rel and does not exhibit a preference between these Rel proteins. Instead the primary difference between I kappa B-alpha and I kappa B-beta is in their response to different inducers of NF-kappa B activity. One class of inducers causes rapid but transient activation of NF-kappa B by primarily affecting I kappa B-alpha complexes, whereas another class of inducers causes persistent activation of NF-kappa B by affecting both I kappa B-alpha and I kappa B-beta complexes. Therefore, the overall activation of NF-kappa B consists of two overlapping phases, a transient phase mediated through I kappa B-alpha and a persistent phase mediated through I kappa B-beta. |
| Document Type: Article |
| Language: English |
Addresses:
1. YALE UNIV, SCH MED, HOWARD HUGHES MED INST, IMMUNOL SECT, NEW HAVEN, CT 06520 USA
2. YALE UNIV, SCH MED, HOWARD HUGHES MED INST, DEPT MOLEC BIOPHYS & BIOCHEM, NEW HAVEN, CT 06520 USA
3. MEM SLOAN KETTERING CANC CTR, MOLEC BIOL PROGRAM, NEW YORK, NY 10021 USA |
| Publisher: CELL PRESS, 50 CHURCH ST CIRCULATION DEPT, CAMBRIDGE, MA 02138 |
| Subject Category: Biochemistry & Molecular Biology; Cell Biology |
| IDS Number: QJ602 |
| ISSN: 0092-8674 |
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