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| LACTOSE AND GALACTOSE INTAKE AND METABOLISM IN RELATION TO THE RISK OF EPITHELIAL OVARIAN-CANCER |
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| Author(s): HERRINTON LJ, WEISS NS, BERESFORD SAA, STANFORD JL, WOLFLA DM, FENG ZD, SCOTT CR |
| Source: AMERICAN JOURNAL OF EPIDEMIOLOGY Volume: 141 Issue: 5 Pages: 407-416 Published: MAR 1 1995 |
| Times Cited: 39 References: 24 |
| Abstract: It has been suggested that aspects of lactose consumption and metabolism favoring a relatively high tissue level of galactose-1-phosphate may predispose women to ovarian cancer. The authors sought to examine this hypothesis in a study of 108 18- to 74-year-old Caucasian residents of a three-county area of western Washington who were diagnosed with stage I ovarian cancer during 1989-1991, and 108 age- and race-matched controls. Lactose and galactose intake, measured using a food frequency questionnaire, had been hypothesized to increase risk, but were somewhat lower among the cases than among the controls (75th percentile of lactose intake vs. 25th: odds ratio (OR) = 0.80, 95% confidence interval (CI) 0.52-1.2; of galactose intake: OR = 0.71, 95% CI 0.48-1.1). Intestinal lactase activity, also hypothesized to have a positive relation with ovarian cancer occurrence, was measured with an oral lactose challenge followed by determination of urinary galactose; no evidence that it was related to the disease was found (75th percentile of excreted galactose vs. 25th: OR = 0.87, 95% CI 0.62-1.2). Galactose-1-phosphate uridyltransferase (transferase), the enzyme responsible for the metabolism of galactose-1-phosphate, was measured in erythrocytes; no deficit in cases was observed (75th percentile of transferase activity vs. 25th: OR = 1.3, 95% CI 0.80-2.1). There was also no excess of cases carrying low-activity genetic variants of the transferase enzyme (lower-activity variants vs. higher-activity variants: OR = 0.61, 95% CI 0.21-1.7). These results do not support the hypothesis that aspects of lactose and galactose intake and metabolism have a bearing on the etiology of ovarian cancer. |
| Document Type: Article |
| Language: English |
Addresses:
1. UNIV WASHINGTON, SCH PUBL HLTH & COMMUNITY MED, DEPT EPIDEMIOL, SEATTLE, WA 98195 USA
2. FRED HUTCHINSON CANC RES CTR, DIV PUBL HLTH SCI, SEATTLE, WA 98104 USA
3. CHILDRENS HOSP & MED CTR, DEPT LAB MED, GENET LAB, SEATTLE, WA 98105 USA
4. UNIV WASHINGTON, SCH PUBL HLTH & COMMUNITY MED, DEPT BIOSTAT, SEATTLE, WA 98195 USA
5. UNIV WASHINGTON, MED CTR, DEPT PEDIAT, SEATTLE, WA 98195 USA |
| Publisher: AMER J EPIDEMIOLOGY, 624 N BROADWAY RM 225, BALTIMORE, MD 21205 |
| Subject Category: Public, Environmental & Occupational Health |
| IDS Number: QL096 |
| ISSN: 0002-9262 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |