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| AGING-ASSOCIATED CHANGES IN RENAL EXTRACELLULAR-MATRIX |
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| Author(s): ABRASS CK, ADCOX MJ, RAUGI GJ |
| Source: AMERICAN JOURNAL OF PATHOLOGY Volume: 146 Issue: 3 Pages: 742-752 Published: MAR 1995 |
| Times Cited: 61 References: 39 |
| Abstract: The composition of renal extracellular matrices was examined in 6-, 12-, 18-, and 24-month-old rats by immunofluorescence microscopy. No change in composition of tubular basement membrane was detected. Increased immunostaining for laminin chains B1 and s-laminin and thrombospondin characterized the thickened glomerular basement membrane. Interstitial collagens I and III were not detected is globally sclerotic glomeruli. The major change noted in the aged rat kidney at 24 months was generalized expansion of the interstitium by thrombospondin and fibronectin, In areas of tubular atrophy there was new expression of extra domain A (EDA)(+) fibronectin Collagens I and III were detected focal by in the interstitium adjacent to areas of tubular atrophy, but otherwise collagens I, III, and IV and laminin did not contribute to the interstitial fibrosis, Interstitial fibrosis was detectable at 18 months of age and preceded the development of sclerotic glomeruli, tubular atrophy, or accumulations of interstitial collagen. These changes in extracellular matric composition distinguish the aging kidney from other sclerotic forms of renal disease. |
| Document Type: Article |
| Language: English |
| Reprint Address: ABRASS, CK (reprint author), VET AFFAIRS MED CTR, DEPT MED, DIV NEPHROL, RENAL DIALYSIS UNIT 111A, 1660 S COLUMBIAN WAY, SEATTLE, WA 98108 USA |
Addresses:
1. VET AFFAIRS MED CTR, DEPT MED, DIV DERMATOL, SEATTLE, WA 98108 USA
2. UNIV WASHINGTON, SCH MED, SEATTLE, WA USA |
| Publisher: AMER SOC INVESTIGATIVE PATHOLOGY, INC, 428 EAST PRESTON ST, BALTIMORE, MD 21202-3993 |
| Subject Category: Pathology |
| IDS Number: QL395 |
| ISSN: 0002-9440 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |