| | |  | | | | Record from Web of Science® | | | | | | |
| MECHANISMS AND GENES OF CELLULAR SUICIDE |
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| Author(s): STELLER H |
| Source: SCIENCE Volume: 267 Issue: 5203 Pages: 1445-1449 Published: MAR 10 1995 |
| Times Cited: 1,996 References: 90 |
| Abstract: Apoptosis is a morphologically distinct form of programmed cell death that plays a major role during development, homeostasis, and in many diseases including cancer, acquired immunodeficiency syndrome, acid neurodegenerative disorders. Apoptosis occurs through the activation of a cell-intrinsic suicide program. The basic machinery to carry out apoptosis appears to be present in essentially all mammalian cells at all times, but the activation of the suicide program is regulated by many different signals that originate from both the intracellular and the extracellular milieu. Genetic studies in the nematode Caenorhabditis elegans and in the fruit fly Drosophila melanogaster have led to the isolation of genes that are specifically required for the induction of programmed cell death. At least some components of the apoptotic program have been conserved among worms, insects, and vertebrates. |
| Document Type: Article |
| Language: English |
| Reprint Address: STELLER, H (reprint author), MIT, HOWARD HUGHES MED INST, DEPT BRAIN & COGNIT SCI, CAMBRIDGE, MA 02139 USA |
Addresses:
1. MIT, DEPT BIOL, CAMBRIDGE, MA 02139 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QL497 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |