| | |  | | | | Record from Web of Science® | | | | | | |
| APOPTOSIS IN THE PATHOGENESIS AND TREATMENT OF DISEASE |
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| Author(s): THOMPSON CB |
| Source: SCIENCE Volume: 267 Issue: 5203 Pages: 1456-1462 Published: MAR 10 1995 |
| Times Cited: 4,490 References: 148 |
| Abstract: In multicellular organisms, homeostasis is maintained through a balance between cell proliferation and cell death. Although much is known about the control of cell proliferation, less is known about the control of cell death. Physiologic cell death occurs primarily through an evolutionarily conserved form of cell suicide termed apoptosis. The decision of a cell to undergo apoptosis can be influenced by a wide variety of regulatory stimuli. Recent evidence suggests that alterations in cell survival contribute to the pathogenesis of a number of human diseases, including cancer, viral infections, autoimmune diseases, neurodegenerative disorders, and AIDS (acquired immunodeficiency syndrome). Treatments designed to specifically alter the apoptotic threshold may have the potential to change the natural progression of some of these diseases. |
| Document Type: Review |
| Language: English |
| Reprint Address: THOMPSON, CB (reprint author), UNIV CHICAGO, GWEN KNAPP CTR LUPUS & IMMUNOL RES, HOWARD HUGHES MED INST, DEPT MED, CHICAGO, IL 60637 USA |
Addresses:
1. UNIV CHICAGO, GWEN KNAPP CTR LUPUS & IMMUNOL RES, HOWARD HUGHES MED INST, CHICAGO, IL 60637 USA |
| Publisher: AMER ASSOC ADVAN SCIENCE, 1333 H ST NW, WASHINGTON, DC 20005 |
| Subject Category: Multidisciplinary Sciences |
| IDS Number: QL497 |
| ISSN: 0036-8075 |
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| | | | | | | | | Record from Web of Science® | | | | | | | | | |